Structure of biomolecules and Biorecognition. Antibodies. Part 2

Posted on by Isabel Pividori

Lesson 2

February 18 @ 10:00 – 11:00 CET

Structure of biomolecules and Biorecognition. Amino Acids, Peptides and Proteins. Antibodies. Enzymes. Nucleic Acids. Biorecognition: Enzyme/Substrate. Antigen/antibody. Hybridization. Other affinity interactions in nature. Strept(avidin), Protein A and G. Aptamers.  Biomimetic recognition. The importance of water in biorecognition. Biological buffers.

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AntibodyDownload

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This lecture will be focused on the structure of antibodies. The immune response and the production of antibodies will be discussed with the immunological techniques.

Crossword

Instructions. Solve the crossword, do a screenshot and post it in the forum under the topic Top five challenge!


1. Generic name for a group of glycoproteins find in the serum or in the tissues fluids of all mammals
2. Family of proteins that can be found free in the serum, popular for the Y shape
3. The Fab has the property to bind the .....
4. Heavy chain of the IgG class
5. Polypeptide chain of lower molecular weight in the antibody
6. Type of domain that is in contact with the antibody
7. The most frequent class of immunoglobulin
8. Structure of the IgM
9. Enzyme that cleave the immunoglobulins
10. bond which hold the antibody chains together
11. Number of heavy constants domains in an IgG
12. Number of polypeptide chains in an IgG antibody
13. IgM, IgA, IgG, IgE, and IgD are the antibodies......
14. number of IgG subclasses
15. One of the isotopes for the light chains in immunoglobulins
16. Part of an antibody which provides flexibility
17. Fc, constant part of the antibodies
18. IgG1, IgG2, IgG3, IgG4 are IgG....
19. Type of globular domains that take parts of Fc

Self-assesment quiz (not evaluable)

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Note!! After timer finished countdowning, quiz will be submitted automatically

Antibody structure (self assesment)

Self Assessment Test. This test will help you to revise the separation methods of the proteins and DNA. 

25 questions in 1 page and 30 min!

Hint 1. the response can be multiple or, in most of the instances, simple. You will notice by clicking twice if the question admit only one, or more responses.

1 / 25

Which of the following statements is NOT TRUE of affinity?

2 / 25

Match the immunoglobulin(s) with the functional description:

Involved in allergic responses

3 / 25

Lymphocytes are the main cells involved in our immune system. There are many types of lymphocytes, each with a specific function. Which of the following are involved in producing antibodies?

4 / 25

What is a specific term for a bacterial or other foreign protein that initiates antibody production by the body?

5 / 25

Antibodies of the IgG class

6 / 25

IgM is structurally characterized as:

7 / 25

What fraction of serum are the antibodies (immunoglobulins) found when using electrophoresis?

8 / 25

Match the following descriptions with their term:

Binds to various cellular receptors and to complement

9 / 25

A fragment antigen binding (Fab) fragment:

10 / 25

Pepsin cleaves what region of immunoglobulin?

11 / 25

Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?

12 / 25

Antigenic determinants bind to which portions of an antibody?

13 / 25

Which of the following binds to an Fc receptor on mast cells and basophils?

14 / 25

Match the following descriptions with their term.

Allows for flexibility

15 / 25

Cleavage of an IgG molecule by the protease, papain, produces:

16 / 25

Which of the following statements does NOT apply to IgG?

17 / 25

An epitope is generally used to refer to an area on a much larger molecule (e.g., a viral protein) with which an antibody can react.

18 / 25

IgG consists of

19 / 25

Which of the following statements is true regarding the function of antibodies?

20 / 25

Which of the following factors is NOT true about the immunoglobulin structure?

21 / 25

Match the following descriptions with their term:

Has a crystallizable fragment (Fc) and Fab region

22 / 25

Name the heavy chain of immunoglobulin M

23 / 25

J chain is present in

24 / 25

Which of the following amino acid is found in the hinge region?

25 / 25

The antibody present in secretions like tears and saliva is

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